Sodium Alginate-Based MgO Nanoparticles Coupled Antibiotics as Safe and Effective Antimicrobial Candidates against Staphylococcus aureus of Houbara Bustard Birds

Alternative and modified therapeutic approaches are key elements in culminating antibiotic resistance. To this end, an experimental trial was conducted to determine the cytotoxicity antibacterial potential of composites magnesium oxide (MgO) nanoparticles antibiotics stabilized sodium alginate gel against multi-drug-resistant Staphylococcus aureus isolated from a houbara bustard. The characterization preparations carried out using X-ray diffraction (XRD), scanning transmissible electron microscopy (STEM), Fourier-transform infrared spectroscopy (FTIR). used consisted gel-stabilized MgO (MG), tylosin (GT), ampicillin (GA), cefoxitin (GC), (GMT), (GMC), (GMA). study presents that cause lesser extent damage DNA while significantly enhancing mitotic indices/phases compared other single component with respect positive control (methyl methanesulphonate). It also noted there non-significant difference (p > 0.05) between concentrations negative toxicity trial. Studying parallel trials showed increased prevalence, risk factors, resistance S. aureus. well diffusion highest percentage increase zone inhibition case GT (58.42%), followed by GMT (46.15%), GC (40.65%), GMC (40%), GMA (28.72%), GA (21.75%) alone. A broth microdilution assay lowest minimum inhibitory concentration (MIC) (9.766 ± 00 µg/mL), (13.02 5.64 (19.53 0.00 (26.04 11.28 MG (39.06 µg/mL). thus concludes effective tackling multiple-drug-resistant sodium-alginate-stabilized antibiotics, whereas proved be negligible for these composites.